Topical and Transdermal Diffusion Cell Systems
In Vitro drug diffusion testing of the transfer rate across a membrane is a technology used for the study of skin transfer kinetics and to establish batch-to-batch uniformity of topical preparations. The procedure employs a diffusion cell that separates a donor compartment from a receptor compartment with a specified membrane. Complete turn-key systems for diffusion cell testing are available from Hanson Research and JB Pharmatron.
The MicroettePlus System, supplied by JB Pharmatron, provides automatic sampling from diffusion cells and collection into HPLC vials for sample analysis. The system automates sampling protocols from groups of six diffusion cells for extensive un-attended tests, and handles surfactants, saline and hydroalcoholic receptor solutions.
The new MicroettePlus incorporates Hanson AutoPlus technology, including precision 6-channel syringe pump, Teflon valves and sample tubing, Easy-Icon programming with graphical display, convenient pop-up menus and helps screens, up to 25 test protocols, 21 CFR part 11 compliant software, "smart-switch" for system communications, automatic media replace at time of sampling, programmable cell dilutions, jacketed media replace beaker, and supply kit. A choice of Hanson precision vertical diffusion cells, 6-cell drive system with stainless stand, MultiFill collector with interchangeable HPLC vial rack, validation printer, and heater circulating bath round out the complete system package.
Topical and Transdermal Diffusion Cell Systems
